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Advances in cancer research. Volume 72
Title:
Advances in cancer research. Volume 72
Author:
Klein, George.
ISBN:
9780080562544
9780120066728
9781281409355
9786611409357
Publication Information:
San Diego : Academic Press, 1998.
Physical Description:
1 online resource (x, 242 pages) : illustrations.
Series:
Advances in cancer research ; v. 72
Contents:
Front Cover; Advances in Cancer Research, Volume 72; Copyright Page; Contents; Contributors,Volume 72; Chapter 1. Foulds' Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later; I. Foulds' Rules; II. Oncogenetics; III. Other Destabilizing Mutations Caused by Loss of DNA Repair Functions; IV. Molecular Biology of Multistep Carcinogenesis; V. Strong Selective Pressures Favor Multiple Escapes; VI. Conclusion; References; Chapter 2. Cancer Cells Exhibit a Mutator Phenotype; I. Introduction; II. Historical Perspective; III. Requirements for a Mutator Phenotype
IV. Origins of MutationsV. Candidate Target Mutator Genes; VI. Microsatellite Instability; VII. Theoretical and Practical Considerations; VIII. Summary and Perspectives; References; Chapter 3. Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins; I. Introduction; II. Ras is a Point of Convergence for Diverse Extracellular Signal-Stimulated Pathways; III. Ras Activation of Raf-Independent Pathways Contributes to Ras Transformation; IV. Ras Mediates Its Actions through Interaction with Multiple Effectors
V. Ras Activation of a GTPase Cascade: An Involvement of Rho Family Proteins in TransformationVI. Rho Family Proteins Mediate Their Actions through Interaction with Multiple Effectors; VII. A Search for the Missing Link between Ras and Rho Family Proteins; VIII. Increasing Complexity of Ras Signal Transduction: A Boon or Bust for Drug Discovery and the Development of Anti-Ras Drugs for Cancer Treatment?; IX. Future Directions; References; Chapter 4. B-Myb: A Key Regulator of the Cell Cycle; I. Introduction; II. B-Myb Structure and Functional Domains; III. Transcriptional Regulation of B-rnyb
IV. Modification of B-Myb Protein in the Cell CycleV. The Requirement for B-Myb in Cell Proliferation; VI. B-Myb Function; References; Chapter 5. Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia; I. Introduction; II. Brief History of DNA Methylation in Eukaryotes; III. The Normal Roles for Cytosine Methylation in Higher Order Eukaryotes; IV. Abnormalities of DNA Methylation in Neoplasia; V. Mechanisms Underlying the DNA Methylation Changes in Neoplastic Cells; VI. An Overview of Tumor Progression That Incorporates the Roles of Altered DNA Methylation
VII. Clinical Implications of Altered DNA Methylation in CancerReferences; Chapter 6. Ara-C: Cellular and Molecular Pharmacology; I. Introduction; II. Structure; III. Metabolism; IV. Mechanisms of Cytotoxicity; V. Mechanism of Resistance; VI. Signaling Pathways and Oncogene Interactions; VII. Modulation of ara-C Associated Toxicity; VIII. Conclusions; References; Index
Abstract:
The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.
Genre:
Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780120066728Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| RC267 .A4572 1998 EB | 1179294-1001 | Elsevier E-Book Collections | Searching... |
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