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Advances in cancer research. Volume 78
Title:
Advances in cancer research. Volume 78
Author:
Klein, George.
ISBN:
9780080562599
9780120066780
9781281709370
9786611709372
Publication Information:
San Diego : Academic Press, 2000.
Physical Description:
1 online resource (vii, 345 pages) : illustrations.
Series:
Advances in Cancer Research ; v. 78
Advances in Cancer Research.
Contents:
Front Cover; Advances in Cancer Research, Volume 78; Copyright Page; Contents; Contributors to Volume 78; Chapter 1. Cell Transformation by the E7 Oncoprotein of Human Papillomavirus Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins; I. Background: The Role of Papillomaviruses in Human Cancer; II. Cellular E7-Binding Proteins; III. Modulation of Cellular Functions by E7; IV. The Role of HPV-16 E7 in Cell Proliferation and Immortalization; References; Chapter 2. Tumor Invasion: Role of Growth Facto-lnduced Cell Motility; I. Introduction; II. Tumor Invasiveness.
III. Cell MotilityIV. Motility in Tumor Invasion; V. Therapeutic Interventions; VI. Summary and Future Directions; References; Chapter 3. Nonenzymatic Interactions between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology; I. Introduction; II. Extracellular Matrix-Degrading Proteinases: Classification and Structural Features; III. Proteolysis-Independent Roles of Extracellular Matrix-Degrading Proteinases; IV. Conclusions and Perspectives; References; Chapter 4. Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis.
I. IntroductionII. Histopathogenesis; III. Clinical Features; IV. In Vitro and in Vivo Models; V. Molecular Mechanisms of Kaposi's Sarcoma Cell Growth; VI. Roles of Virus Infections in Kaposi's Sarcoma Development; VII. Apoptosis in Kaposi's Sarcoma Cells; VIII. Concluding Remarks and Therapeutic Implications; References; Chapter 5. Perspectives on Cancer Chemoprevention Research and Drug Development; I. Introduction; II. Nature of Carcinogenesis; III. Definition of Chemoprevention and Chemoprevention Agent Discovery; IV. Chemopreventive Agent Development.
V. Cancer Chemoprevention at Major Cancer Target SitesVI. Surrogate End Points in Defining Chemopreventive Efficacy-Importance of Evaluating Both Phenotypic and Genotypic Effects; VII. Major Issues and Challenges for Cancer Chemoprevention; References; Index.
Abstract:
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Key Features * Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins * Tumor Invasion: Role of Growth Factor-Induced Cell Motility * Non-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology * Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis * Perspectives on Cancer Chemoprevention Research and Drug Development.
Genre:
Electronic Access:
ScienceDirect http://www.sciencedirect.com/science/book/9780120066780Available:*
Shelf Number | Item Barcode | Shelf Location | Status |
|---|---|---|---|
| RC267 .A4578 2000 EB | 1179561-1001 | Elsevier E-Book Collections | Searching... |
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