Front Cover; Progress in Medicinal Chemistry, Volume 6; Copyright Page; Contents; Preface; CHAPTER 1. THE BRITISH PHARMACOPOEIA COMMISSION; Historical introduction; Post-war developments; Legal position of the Pharmacopoeia; Reference substances; Approved names; Future developments; CHAPTER 2. PHARMACOLOGICAL ASPECTS OF THE CORONARY CIRCULATION; Introduction; Clinical implications; Physiological determinants of coronary flow; Mechanisms through which drugs modify coronary flow; Methods of evaluating the action of drugs on the coronary circulation

Naturally occurring substances that modify coronary flowDrugs used in the treatment of angina pectoris; Conclusions; CHAPTER 3. SOME PYRIMIDINES OF BIOLOGICAL AND MEDICINAL INTEREST-PART I; Introduction; 2,4-Diaminopyrimidines and related compounds; Halogenated pyrimidines; Sulphur-substituted pyrimidines; 2-Substituted 4-amino-5-hydroxymethylpyrimidine and related compounds; Pyrimidine sulphonamides; Pyrimidine and condensed pyrimidine antibiotics; CHAPTER 4. THE MECHANISM OF ACTION OF SOME ANTIBACTERIAL AGENTS; Introduction; Antibacterial agents and bacterial cell walls

Antibacterial agents and cytoplasmic membranesSubstances inhibiting protein and nucleic acid syntheses; Metal-binding and antibacterial action; Addendum; CHAPTER 5. THE BIOSYNTHESIS AND METABOLISM OF THE CATECHOLAMINES; Historical introduction; Catecholamine biosynthesis; D-DOPA and D-amino acid oxidase; L-DOPA; Dopamine; Noradrenaline and adrenaline; Enzymes responsible for catecholamine biosynthesis; Metabolism of catecholamines; Enzymes involved in metabolism of catecholamines; CHAPTER 6. THE LITERATURE OF MEDICINAL CHEMIS'IRY; Introduction; General textbooks and monographs

Relationship between chemical structure and biological activity (including receptor sites, stereochemical aspects)Spectroscopic and other analytical techniques; Radiochemical and radiobiological topics; Alkaloids; Amino acids, peptides and proteins; Carbohydrates of medicinal interest; Enzymes and enzyme inhibitors; Heterocyclic compounds of medicinal interest; Hormones and prostaglandins; Lipids and atherosclerosis; Metals and their chelates; Nucleosides, nucleotides and nucleic acids; Phosphorylated compounds; Steroids; Various organic chemical groups of medicinal interest; Vitamins

Transport and metabolism of drugsDrugs and the central nervous system; Local anaesthetic drugs; Antitussive drugs; Drugs and the peripheral nervous system; Histamine, 5-hydroxytryptamine and their antagonists; Non-steroidal anti-inflammatory drugs; Immunochemistry and allergy; Hypoglycaemic drugs; Diuretic and antidiuretic drugs; Blood and cardiovascular disorders; Anticancer agents; Psychopharmacological drugs; Chemotherapy; Uricosuric drugs; Radiopaque agents; Patenting of drugs; Miscellaneous topics; Addendum; Index