Front Cover; Annual Reports in Medicinal Chemistry, Volume 25; Copyright Page; CONTENTS; Contributors; Preface; SECTION I: CNS AGENTS; Chapter 1. Novel Antipsychotic Agents; Chapter 2. Analgesics; Chapter 3. Cognition Enhancers; Chapter 4. Acute Ischemic and Traumatic Injury to the CNS; Chapter 5. Advances in Central Serotonergics; SECTION II: CARDIOVASCULAR AND PULMONARY AGENTS; Chapter 6. Antihypertensive Agents; Chapter 7. Pulmonary and Antiallergy Agents; Chapter 8. Treatment of Acute Myocardial Ischemia; Chapter 9. Antiarrhythmic Agents; Chapter 10. Endogenous Vasoactive Peptides

Chapter 11. Thromboxane Synthase Inhibitors and Receptor AntagonistsSECTION III: CHEMOTHERAPEUTIC AGENTS; Chapter 12. Antibacterial Agents; Chapter 13. Macrolide Antibiotics; Chapter 14. Mechanism-Based Discovery of Anticancer Agents; Chapter 15. Targets for Antifungal Drug Discovery; Chapter 16. Recent Advances in Anti-retroviral Chemotherapy for AIDS; SECTION IV: METABOLIC DISEASES AND ENDOCRINE FUNCTION; Chapter 17. Agents for the Treatment of Peptic Ulcer Disease; Chapter 18. Modified Serum Lipoproteins and Atherosclerosis

Chapter 19. Biochemistry and Inhibition of Collagenase and StromelysinChapter 20. Pharmacological Modulation of Interleukin-1; Chapter 21. Macrocyclic Immunomodulators; Chapter 22. New Approaches to Diabetes; SECTION V: TOPICS IN BIOLOGY; Chapter 23. Role of Corticotropin-Releasing Factor in Neuropsychiatric Disorders and Neurodegenerative Diseases; Chapter 24. Ligand-Gated and Voltage-Gated Ion Channels; Chapter 25. Cell Adhesion Molecules; Chapter 26. Action of Neurotrophic Factors on Central Nervous System Neurons

Chapter 27. The Structure of the Multidrug Resistance P-Glycoprotein and its Similarity to Other ProteinsSECTION VI: TOPICS IN CHEMISTRY AND DRUG DESIGN; Chapter 28. New Directions in Positron Emission Tomography-Part II; Chapter 29. Irreversible Ligands for Drug Receptor Characterization; Chapter 30. Progress in the Characterization of Peptide Receptors; Chapter 31. The Impact of Biotechnology on Drug Discovery; Chapter 32. Catalytic Antibodies: A New Class of Designer Enzymes; SECTION VII: TRENDS AND PERSPECTIVES; Chapter 33. To Market, To Market-1989

Chapter 34. Significance of Drug Stereochemistry in Modern Pharmaceutical Research and DevelopmentChapter 35. Twenty-Five Years of Annual Reports in Medicinal Chemistry; Compound Name, Code Number, and Subject Index, Volume 25; Cumulative Chapter Titles Keyword Index, Volumes 1-25; Cumulative Contributor Index, Volumes 1-25; Cumulative NCE Introduction Index, 1983-1989; Cumulative NCE Introduction Index, 1983-1989, by Indication