Front Cover; Advances in Cancer Research; Copyright Page; Contents; Contributors; Chapter 1: Mechanisms of Prostate Cancer Initiation and Progression; I. Epidemiologic Studies in Prostate Cancer; II. The Architecture of the Normal Prostate Gland; III. Development and Maintenance of the Prostate Gland; IV. Morphological and Cytological Changes that Take Place During Prostate Cancer Initiation and Progression; V. Early Genetic and Epigenetic Events in the Transition from Normal Prostate to PIN and Invasive Cancer; VI. Transition to High-Grade Carcinoma and Metastasis

VII. Mechanisms of Castration-Resistant Prostate CancerVIII. Summary and Future Directions; Acknowledgments; References; Chapter 2: Genetic Basis for Susceptibility to Lung Cancer: Recent Progress and Future Directions; I. Introduction: Overview of Studies on Genetic and Environmental Factors Involved in Lung Cancer Susceptibility; II. Differences in the Process of Lung Cancer Development Between Smokers and Never-Smokers; III. Candidate Gene Association Studies; IV. Genome-Wide Association Studies

V. Assessment of Lung Cancer Risk in Each Individual by Combined Genotypes (Gene-Gene Interactions)VI. Smoking-Associated Differences (Gene-Environment Interactions); VII. Necessity of Further Association Studies; VIII. Future Directions; Acknowledgments; References; Chapter 3: Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4; I. Introduction; II. Phylogenetic Evolution, Structure, and Tissue Distribution of CSPG4; III. Functional Properties of CSPG4; IV. Clinical Applications of CSPG4; V. Conclusion; Acknowledgments; References

Chapter 4: KRAS Signaling Pathway Alterations in Microsatellite Unstable Gastrointestinal CancersI. Mismatch Repair, MSI, and Related Target Genes; II. MSI-H Phenotype-Related Molecular and Clinicopathologic Features; III. MSI-H-Related Epigenetic Features: CpG island Methylator Phenotype; IV. MSI-H-Related Genetic Features: The KRAS Signaling Pathway; V. A Serrated Carcinogenesis Pathway in the Origin of Sporadic MSI CRC; VI. Conclusions; References; Index