Foreword / Foreword / Preface / Discovery and Classification of Human Herpesvirus-6 (HHV-6) / Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6) / HHV-6 Genome: Similar and Different / Proteins of HHV-6 / Biological Features of HHV-6 / Strain Variants of HHV-6 / Serologic Testing for Acute and Chronic Infection / Molecular Testing for HHV-6 Infection / Epidemiology of HHV6 / Pathologic Features of HHV-6 Disease / Systemic Reactions to HHV-6 Infection / HHV-6 and the Integument / HHV-6 and the Respiratory System / HHV-6 and the Lympho-Hematopoietic System / Human Herpesvirus-6 and the Cellular Immune System / HHV-6 and the Central Nervous System / HHV-6 and the Cardiovascular System / HHV-6 in Cardiovascular Pathology / HHV-6, the Liver and the Gastrointestinal Tract / HHV-6 in Chronic Fatigue Syndrome / HHV-6 and HIV-1 Infection / Human Herpesvirus-6 Infection in Solid Organ and Stem Cell Transplant Recipients / Therapeutic Approaches to HHV-6 Infection / Animal Models / Computational Simulation of HHV-6 Infection / Experimental Therapeutic Approaches.

Cover -- Contents -- Foreword by Robert Gallo -- Foreword by Ronald Glaser and Marshall Williams -- Preface -- Part I: General Virology -- Discovery and Classification of Human Herpesvirus-6 (HHV-6) -- Discovery -- Nomenclature and classification -- References -- Ultrastructure and Assembly of Human Herpesvirus-6 (HHV-6) -- Introduction -- Herpesvirus-6 assembly and maturation -- Three-dimensional structure of HHV-6 capsid -- Comparision of the HHV-6 cappsid structure with those of other human herpesviruses -- Conclusion -- References -- HHV-6 Genome: Similar and Different -- Genome classification and biology -- Genomes, cellular tropism and laboratory culture -- Genome structure and repetitive sequence -- Genome rearrangements and relationship to other herpesviruses -- Genome composition and general molecular biology -- Herpesvirus conserved and HHV-6-specific genes -- Genomes and HHV-6 strains -- Acknowledgements -- References -- Proteins of HHV-6 -- Introduction -- IE proteins -- U16/U17 -- U53, proteinase -- U69, kinase -- Cellular homologues -- U94, AAV-2 rep homologue -- Envelope glycoproteins -- U39, gB -- U48 and U82, gH and gL -- U100, gQ -- U47, gO -- U11 -- U14 -- U27 -- Perspective -- References -- Biological Features of HHV-6 -- Introduction -- HHV-6 cellular receptor -- Species specificity -- Cellular tropism of HHV-6 -- Biological effects of HHV-6 on the host cell -- References -- Part II: Diagnosis and Epidemiology -- Strain Variants of HHV-6 -- Introduction -- Epidemiology -- Molecular biology -- Biological aspects of variants A and B -- Reactivity of monoclonal antibodies to HHV-6 variants A and B -- Disease associations of HHV-6A and -6B variants -- Concluding remarks -- References -- Serologic Testing for Acute and Chronic Infection -- Introduction -- Serologic assays -- Serologic findings -- Pending questions and perspectives -- Acknowledgments -- References -- Molecular Testing for HHV-6 Infection -- Introduction -- Primary infection: characteristics and diagnostic considerations -- PCR analysis of cell-free body fluids -- Reverse transcription PCR analysis -- Quantitative PCR analysis of HHV-6 DNA in PBMC or blood -- Detection of virus variants -- Other assay approaches -- Future assay methods -- PCR-based assays: general considerations and molecular underpinnings -- Commercially available tests -- General considerations for current molecular assays -- References -- Epidemiology of HHV6 -- The epidemiology of roseola from historical observations -- Seroepidemiologic studies of HHV6 infection -- Acquisition of HHV6 infection during childhood -- Acquisition of HHV6 infection according to variant -- Factors affecting acquisition of HHV6 infection -- Mode of transmission -- Incubation period -- Summary -- References -- Part III: Clinical Pathology -- Pathologic Features of HHV-6 Disease -- Introduction -- Cell and tissue tropism and strain differences -- General cellular pathology of HHV-6 infection -- Primary infection -- Reactivation and endogenous reinfection -- Conclusions -- References -- Systemic Reactions to HHV &