Cover -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Therapeutic Cloning and Tissue Engineering -- I. Introduction -- II. Principles of Tissue Engineering -- III. Stem Cells -- IV. Therapeutic Cloning -- V. Applications of Tissue Engineering and Therapeutic Cloning -- References -- Chapter 2. a-Synuclein: Normal Function and Role in Neurodegenerative Diseases -- I. Introduction to the Synuclein Protein Family -- II. Synuclein in Synaptic Development and Maintenance -- III. Synuclein Protein Interactions -- IV. Synucleinopathies -- V. Structural Properties of a-Synuclein Protein -- VI. Implications of Oxidative and Nitrative Injury in Synucleinopathies -- VII. Effects of Oxidation and Nitration on a-Synuclein Fibril Formation -- VIII. Possible Role of Pesticides and Other Toxic Chemicals in PD -- IX. Transgenic and Nontransgenic Animal Models of Synucleinopathies -- X. Concluding Remarks -- Acknowledgments -- References -- Chapter 3. Structure and Function of Eukaryotic DNA Methyltransferases -- I. DNA Methylation: A Heritable Epigenetic Mark -- II. Eukaryotic DNA Methyltransferases -- III. Function of DNA Methylation -- IV. Concluding Remarks -- Acknowledgments -- References -- Chapter 4. Mechanical Signals as Regulators of Stem Cell Fate -- I. Introduction -- II. Mechanical Regulation of Limb Development -- III. Theoretical Models of Mechanical Stress in Development -- IV. In Vivo Experimentation -- V. In Vitro Experimentation -- VI. Conclusions -- Acknowledgment -- References -- Chapter 5. Origins of Mammalian Hematopoiesis: In Vivo Paradigms and In Vitro Models -- I. Introduction: The Hematopoietic System -- II. Hematopoiesis: De Muribus et Maribus -- III. Points of Divergence Between Murine and Human Blood Formation -- IV. Hematopoiesis from Embryonic Stem Cells -- V. What Remains To Be Learned? -- VI. Summary -- Acknowledgments -- References -- Chapter 6. Regulation of Gene Activity and Repression: A Consideration of Unifying Themes -- I. Introduction -- II. Regulation of Imprinted Gene Activity and Repression -- III. A Consideration of Recurrent Themes -- References -- Chapter 7. Molecular Basis for the Chloride Channel Activity of Cystic Fibrosis Transmembrane Conductance Regulator and the Consequences of Disease-Causing Mutations -- I. Introduction -- II. Role of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channel Function in Tissue Physiology and Pathophysiology -- III. Cell Biology of CFTR and the Major CF Mutant (delta F508) -- IV. Quaternary Structure of CFTR -- V. The Permeation Pore of CFTR -- VI. Molecular Basis for Regulation by Phosphorylation -- VII. Molecular Basis for Regulation by Nucleotides -- VIII. Future Directions -- Acknowledgments -- References -- Index -- Contents of Previous Volumes -- Last Page.