Front Cover; Advance in Immunology; Copyright Page; Contents; References; Contributors; Chapter 1. Exploiting the Immune System: Toward New Vaccines against Intracellular Bacteria; I. Introduction; II. General Comments; III. Infectious Diseases Caused by Intracellular Bacterial Pathogens; IV. Intracellular Bacteria, Their Niches in the Host Cell, and the Immune Responses Elicited; V. Vaccines; VI. From Genomes to Antigens; VII. Concluding Remarks and Outlook; Chapter 2. The Cytoskeleton in Lymphocyte Signaling; I. Introduction; II. Overview

V. Cytoplasmic Actions of SmadsVI. Actions of Smads in the Nucleus; VII. I-Smads; VIII. Signaling Cross-Talk; IX. Roles of Smads in Human Cancer; X. In Vivo Functions of Smads: Analyses by Gene Targeting; XI. Perspectives/Conclusion; References; Chapter 4. MHC Class II-Restricted Antigen Processing and Presentation; I. Introduction; II. The MHC Class I and Class II Pathways; III. Structure of MHC Class II Complexes; IV. Biosynthesis and Assembly of MHC Class II/Invariant Chain Complexes; V. Entry of MHC Class II/Invariant Chain Complexes into the Endocytic Pathway

VI. Subcellular Organelles Involved in Antigenic Peptide Loading onto Class II Molecules: The MHC Class II CompartmentsVII. Transport of MHC Class II Complexes to the Cell Surface; VIII. Antigen Internalization; IX. Antigen Processing; X. The Biology of a Prime Antigen-Presenting Cell: The Dendritic Cell System; XI. Subversion of MHC Class II-Restricted Antigen Presentation by Pathogens; XII. Conclusions; References; Chapter 5. T-Cell Receptor Crossreactivity and Autoimmune Disease; I. Introduction; II. Crossreactivity and T-Cell Activation

III. Limits of TCR Crossreactivity: Peripheral Purging of Useless T-CellsIV. TCR Crossreactivity and Autoimmune Disease: Viral-Derived Peptide Agonists; IV. Synergies between 3 Enhancers; V. Cytokine Checkpoints in the Generation of Autoimmune Disease; V. DNA-Binding Proteins; References; Chapter 6. Strategies for Immunotherapy of Cancer; I. Introduction; II. Natural Protective Immunity against Cancer; III. Antigens Eliciting T Cell Responses Expressed by Virus-Associated Tumors; IV. Antigens Eliciting T Cell Responses by Non-Virus-Induced Tumors; V. Processing of Tumor Antigens