Advances in Cancer Research is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Topics covered in Volume 67 include a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples; the genetics of murine lung tumors; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis. There are two reviews discussing angiogenesis: the first focuses on the role of scatter factor and the second, the VEGF-FH receptor system. The "Foundations in Cancer Research" article by Alfred G. Knudson is a personal account of his career studying mutation and cancer. Highlights * A "Foundations in Cancer Research" article by Alfred G. Knudson, a personal account of his career studying mutation and cancer * A developmental model of progenitor cell oncogenesis based on a disruption of transcriptional control * Pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples * A review of the genetics of murine lung tumors * Molecular pathogenesis of AIDS-related lymphomas * HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development * A summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis * The role of scatter factor in angiogenesis * The role of the VEGF-FH receptor system in normal and tumor angiogenesis.