Cover; Contents; Chapter 1. Chloroethylnitrosourea Cancer Chemotherapeutic Agents; I. Introduction; II. Development of New Chloroethylnitrosoureas; III. Chemistry; IV. Reactive Intermediates; V. Active Species; VI. Mechanism of Cytotoxicity; VII. Biodisposition; VIII. Chemicobiological Interactions; IX. Conclusion; References; Chapter 2. The Interaction of Cancer Chemotherapy Agents with Mononuclear Phagocytes; I. Introduction; II. Effects of Chemotherapeutic Agents on Mononuclear Phagocytes; III. Effects of Chemotherapeutic Agents on Tumor-Associated Macrophages (TAM)

IV. Antitumor Efficacy and Modulation of Mononuclear PhagocytesV. Concluding Remarks; References; Chapter 3. Mebendazole and Related Anthelmintics; I. Introduction; II. Chemistry and Pharmacology; III. Benzimidazole Carbamates in Veterinary Medicine; IV. Benzimidazole Carbamates in Human Medicine; V. Conclusion; References; Chapter 4. Chemotherapy of Human Intestinal Helminthiasis: A Review with Particular Reference to Community Treatment; I. Summary; II. Introduction; III. The Parasites; IV. The Human Host; V. The Drugs; VI. Therapeutic Intervention; References

Chapter 5. Development of Radiosensitizers: A Medicinal Chemistry PerspectiveI. Introduction; II. General Background; III. Structure Activity/Toxicity Determinants; IV. Medicinal Chemistry of Electron-Affinic Radiosensitizers; V. Summary and Perspectus for the Future; References; Chapter 6. The Effects of Antineoplastic Therapy on Growth and Development in Children; I. Introduction; II. Antineoplastic Therapy; III. Central Nervous System Toxicity; IV. Endocrine Organ Toxicity; V. Skeletal Growth; VI. Psychosocial Development; VII. Concluding Remarks; References

Chapter 7. Biological Properties of ICRF-159 and Related Bis(diox0piperazine) CompoundsI. Historical; II. Chemistry and Structure-Activity Relationships; III. Biological Characteristics; IV. Radiosensitization; V. Pharmacology; VI. Toxicology; VII. Clinical; VIII. Interactions of ICRF Compounds with Other Agents; IX. Prospective Views; References; Note Added in Proof; Index