Front Cover; Advances in Immunology; Copyright Page; Contents; Contributors; Chapter 1: Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus; 1. Introduction; 4. Class Switch Recombination and Somatic Hypermutation; Chapter 2: DNA-PK: The Means to Justify the Ends?; 1. Introduction; 2. Composition; 3. DNA Binding and Kinase Activation; 10. End Processing to Promote End Conservation; References; Chapter 3: Thymic Microenvironments for T-Cell Repertoire Formation; 2. Trafficking of Developing Thymocytes; 3. Cortical Microenvironment; Acknowledgments.

Chapter 4: Pathogenesis of Myocarditis and Dilated Cardiomyopathy2. The Evidence for an Autoimmune Process in Myocarditis; 3. Mouse Models of Myocarditis; 4. Role of Proinflammatory Cytokines in Myocarditis; 5. Role of T Helper Cells in Myocarditis; 7. Conclusions/Directions for Future Research; Acknowledgments; References; Chapter 5: Emergence of the Th17 Pathway and Its Role in Host Defense; 1. Introduction; 3. Functions of the Th17-Derived Cytokines; 4. IL-23/IL-17-Mediated Innate Immunity; 5. Th17 Cells and Innate Immunity.

7. IL-23/IL-17-Mediated Responses in Specific Microbial Infections8. Closing Remarks; Chapter 6: Peptides Presented In Vivo by HLA-DR in Thyroid Autoimmunity; 3. Natural Ligands for HLA Class II in Autoimmune Thyroid Tissue; Acknowledgments; References; Subject Index; Contents of Recent Volumes; Color Plates.