Paper is used in chromatography since the 19th century to detect the presence of certain molecules like proteins, amino acids etc. Point of Care Diagnostics using paper has seen an exponential growth amongst the research community since the last decade. This explosion in the interest was seen after the Whitesides group demonstrated the detection of glucose and protein in 5 microL of urine sample using a device containing hydrophobic and hydrophilic paper. They find applications in a variety of field like the detection of infectious diseases, hormones and metabolites in biological fluids, food borne pathogen detection and even in environmental monitoring. In this study, we have used paper for designing devices capable of performing complex biological assays. We have designed a completely mechanical switch made of paper and mylar which is analogous to an electrical diode and mosfet. A microfluidic device capable of sequencing two is designed and biological assays are conducted to prove its capability. Further, Complex devices capable of sequencing three reagents are designed and tested.