The purpose of this retrospective cohort study was to evaluate the radiographic and clinical outcome of the Resilon/EpiphanyTM obturation system and to determine if Resilon differed in healing. In part 1, 125 teeth were radiographically evaluated using Orstavik's PAI; 80 treated with Resilon and 45 with gutta percha. Age, gender, tooth position and number of months to follow up were documented and a multivariate analysis was performed. Resilon treated teeth were more likely to have a lesion at follow up when compared to gutta percha (p=0.009). Teeth presenting with pre-operative lesions, regardless of material used, were also more likely to present with a lesion at follow up (p=0.04). In part 2, 38 subjects were clinically evaluated. Bivariate analysis showed no difference in any clinical signs between Resilon and gutta percha and placement of a final restoration within 3 months of root canal completion, regardless of material, was beneficial (p=0.047).