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Florida Agricultural and Mechanical University. Basic Pharmaceutical Sciences. degree granting institution.

(2)

Sackler School of Graduate Biomedical Sciences (Tufts University). Pharmacology and Drug Development. degree granting institution.

(2)

University of Glasgow (United Kingdom). Department of Pharmacology. degree granting institution.

(2)

Alghamdi, Ali A., author.

(1)

Angeli, Mia, author.

(1)

Carlile, David John, author.

(1)

Cobourne-Duval, Makini K., author.

(1)

Ferguson, Jillian, author.

(1)

Humphreys, Jane, author.

(1)

Joseph, Wael R., author.

(1)

Long Island University, The Brooklyn Center. degree granting institution.

(1)

Ma, Zhijun, author.

(1)

McKillop, David, author.

(1)

Morgan, Edward Thomas, author.

(1)

Nkembo, Augustine T., author.

(1)

Robertson, Naomi, author.

(1)

The University of Manchester (United Kingdom). Department of Chemistry. degree granting institution.

(1)

The University of Manchester (United Kingdom). Department of Pharmacy. degree granting institution.

(1)

The University of Manchester (United Kingdom). School of Pharmacy and Pharmaceutical Sciences. degree granting institution.

(1)

University of California, Los Angeles. Chemistry 0153. degree granting institution.

(1)

University of Cincinnati. Pharmacy. degree granting institution.

(1)

University of Glasgow (United Kingdom). Department of Chemistry. degree granting institution.

(1)

Van Valkenburgh, Juno Simone, author.

(1)

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Pharmaceutical sciences.

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Organic chemistry.

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Cellular biology.

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Molecular biology.

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Molecular chemistry.

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Library

Başkent Library

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Proquest E-Thesis Collection

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Cover image for Development of Small-Molecule Modulators of Nucleotide Metabolism Enzymes

Development of Small-Molecule Modulators of Nucleotide Metabolism Enzymes

1.

Development of Small-Molecule Modulators of Nucleotide Metabolism Enzymes

by

Van Valkenburgh, Juno Simone, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:13811800

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Excerpt:

Development of Small-Molecule Modulators of Nucleotide Metabolism Enzymes / Van Valkenburgh, Juno

Cover image for Experimental methods to elucidate the toxic effects of organophosphates on GSTM and GSTP

Experimental methods to elucidate the toxic effects of organophosphates on GSTM and GSTP

2.

Experimental methods to elucidate the toxic effects of organophosphates on GSTM and GSTP

by

Alghamdi, Ali A., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10868681

Format:

Excerpt:

. Glutathione S-transferase enzymes (GSTs) are a group of phase II enzymes that work by catalyzing the

Cover image for Pharmacokinetics of Fentanyl in Epileptic Patients During Concomitant Therapy with Phenytoin or Carbamazepine

Pharmacokinetics of Fentanyl in Epileptic Patients During Concomitant Therapy with Phenytoin or Carbamazepine

3.

Pharmacokinetics of Fentanyl in Epileptic Patients During Concomitant Therapy with Phenytoin or Carbamazepine

by

Ma, Zhijun, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10784643

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Excerpt:

of cytochrome P450 enzymes, causing increased hepatic clearance of fentanyl in epileptic patients. To

Cover image for Neonatal Abstinence Syndrome: Comparing the Hepatic Metabolism of Addictive Medicines in vitro in the Fetus, Neonate and Adult Female

Neonatal Abstinence Syndrome: Comparing the Hepatic Metabolism of Addictive Medicines in vitro in the Fetus, Neonate and Adult Female

4.

Neonatal Abstinence Syndrome: Comparing the Hepatic Metabolism of Addictive Medicines in vitro in the Fetus, Neonate and Adult Female

by

Angeli, Mia, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10751173

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Excerpt:

, neonate and adult female livers. Since the cytochrome P450 3A enzymes (CYP3A4 and CYPA5) are common and

Cover image for Physical Characterization of Vernix Caseosa: Implications for Biological Function

Physical Characterization of Vernix Caseosa: Implications for Biological Function

5.

Physical Characterization of Vernix Caseosa: Implications for Biological Function

by

Joseph, Wael R., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10857220

Format:

Excerpt:

The induction of cytochrome P450 (CYP) 3A enzymes (human isoform, CYP3A4) is a common cause of

Cover image for The synthesis of gem-difluoroshikimic acid derivatives

The synthesis of gem-difluoroshikimic acid derivatives

6.

The synthesis of gem-difluoroshikimic acid derivatives

by

Humphreys, Jane, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10871028

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Excerpt:

enzyme chorismate synthase is detailed. Known inhibitors of enzymes of the pathway, their syntheses and

Cover image for The binding and metabolism of catecholamines by the hepatic microsomal mixed-function oxidase of the rat

The binding and metabolism of catecholamines by the hepatic microsomal mixed-function oxidase of the rat

7.

The binding and metabolism of catecholamines by the hepatic microsomal mixed-function oxidase of the rat

by

McKillop, David, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10868255

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Excerpt:

monoamine oxidase and catechol 0-methyltransferase, the main physiological enzymes of catecholamine

Cover image for The Antioxidant and Anti-inflammatory Basis of the Neuroprotective Effect of Thymoquinone in Activated BV-2 Murine Microglia Cells

The Antioxidant and Anti-inflammatory Basis of the Neuroprotective Effect of Thymoquinone in Activated BV-2 Murine Microglia Cells

8.

The Antioxidant and Anti-inflammatory Basis of the Neuroprotective Effect of Thymoquinone in Activated BV-2 Murine Microglia Cells

by

Cobourne-Duval, Makini K., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10747174

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Excerpt:

assessing the levels of specific oxidative stress markers, the activities of selected antioxidant enzymes

Cover image for Disrupting Polyisoprenylated Protein Function for Pancreatic Cancer Therapy

Disrupting Polyisoprenylated Protein Function for Pancreatic Cancer Therapy

9.

Disrupting Polyisoprenylated Protein Function for Pancreatic Cancer Therapy

by

Nkembo, Augustine T., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10191059

Format:

Excerpt:

polyisoprenylation catalyzed by enzymes for proper membrane localization and signaling. The polyisoprenylated

Cover image for Synthesis of novel compounds for evaluation of anti-cancer activity

Synthesis of novel compounds for evaluation of anti-cancer activity

10.

Synthesis of novel compounds for evaluation of anti-cancer activity

by

Ferguson, Jillian, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10867926

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Excerpt:

drug, the corresponding ortho-quinone. Reaction of this cytotoxic species with essential enzymes within

Cover image for The sensitivity of human tumour cells to quinone-based bioreductive anticancer agents

The sensitivity of human tumour cells to quinone-based bioreductive anticancer agents

11.

The sensitivity of human tumour cells to quinone-based bioreductive anticancer agents

by

Robertson, Naomi, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10867525

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Excerpt:

appropriate reductase enzymes for the activation process. This study has focused on one class of bioreductive

Cover image for An assessment of isolated hepatocytes as an in vitro system for predicting clearance

An assessment of isolated hepatocytes as an in vitro system for predicting clearance

12.

An assessment of isolated hepatocytes as an in vitro system for predicting clearance

by

Carlile, David John, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10870925

Format:

Excerpt:

, mimic intersubject variability of the human drug metabolising enzymes. The level of prediction increased

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