Search Results for Values.

Cover image for Predicting Resistance To Investigational Microbicides Dapivirine and MIV-150 Using Structure-based Methods and Fluorescence Enzyme Inhibition

1.

Predicting Resistance To Investigational Microbicides Dapivirine and MIV-150 Using Structure-based Methods and Fluorescence Enzyme Inhibition

by

Muwonge, Alecia, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10868699

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(DeltaA) and stability (DeltaS) imparted by the mutation. The DeltaA + DeltaS values for K 101 P predict

Cover image for Anthocyanin and Phenolic Derivatives in Blueberry Juice Produce CYP3A Inhibition in vitro, and Identification of These Compounds and Related Derivatives in Human Plasma

2.

Anthocyanin and Phenolic Derivatives in Blueberry Juice Produce CYP3A Inhibition in vitro, and Identification of These Compounds and Related Derivatives in Human Plasma

by

Yu, Xiao, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10751021

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microsome in a concentration-dependent manner featuring IC50 values from 8.8uM up to 89.2uM. To better

3.

An investigation of a new phosphaturic bioassay of parathyroid hormone in the rat

by

Studzinska-Tribedi, Krystyna Zofia, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10867795

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, when calculated as an increase above the corresponding control values, was not significantly affected

4.

Disrupting Polyisoprenylated Protein Function for Pancreatic Cancer Therapy

by

Nkembo, Augustine T., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10191059

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examined. PCAIs induced apoptosis with EC 50 values ranging from 2.4 to 5.1, 2.0 to 7.3, 1.8 to 3.3 and 7.0

5.

Polyisoprenylated Methylated Protein Methyl Esterase as a Putative Biomarker and Drug Target for Prostate Cancer

by

Poku, Rosemary A., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10239054

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cells. The PMPMEase inhibitor, L-28 induced apoptosis with EC 50 values ranging from 1.8 to 4.6 microM

Cover image for Quantitative prediction of drug-drug interactions resulting from cytochrome P450 inhibition using microsomes and hepatocytes

6.

Quantitative prediction of drug-drug interactions resulting from cytochrome P450 inhibition using microsomes and hepatocytes

by

Brown, Hayley Susan, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10871003

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. Comparable Ki values were also obtained between systems for the other compounds studied, with a difference in

7.

Tissue distribution and metabolism studies for a series of barbiturates

by

Ballard, Peter G., author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10870951

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following i.v. bolus dosing and in vitro incubation. Kpue values increased with increasing barbiturate LogP

8.

An assessment of isolated hepatocytes as an in vitro system for predicting clearance

by

Carlile, David John, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10870925

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predictions for diazepam in UT, PB and DEX treated rats were compared with the corresponding microsomal values

9.

The release of catecholamines by nerve stimulation from the guinea-pig vas deferens

by

Macrae, Iseabail Mhairi, author.

http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10867879

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'predicted' values for spontaneous overflow were calculated from CA recovery data in control conditions and

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