Front Cover; International Review of Neurobiology, Volume 36; Copyright Page; Contents; Chapter 1. Ca2+, N-Methyl-D-aspartate Receptors, and AIDS-Related Neuronal Injury; I. Introduction; II. Neuronal Loss in the CNS of AIDS Patients; III. gpl20-Induced Neuronal Injury Is Ameliorated by Calcium Channel Anotagonists; IV. Involvement of the NMDA Receptor in gpl20-Induced Neuronal Injury; V. Indirect Neuronal Injury Mediated by HIV-Infected or gp120-Stimulated Monocytic Cells; VI. Possible Involvement of Astrocytes, Oligodendrocytes, and Other HIV-1 Proteins in Neuronal Injury

VII. Overstimulation of NMDA Receptors, a Final Common PathwayVIII. Development of Clinically Tolerated NMDA Antagonists for HIV-Related Neuronal Injury; IX. Excitatory Amino Acid Antagonist Treatments on the Horizon; X. Conclusion; References; Chapter 2. Processing of Alzheimer Aß-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease; I. Introduction; II. Alzheimer Disease Is Associated with an Intracranial Amyloidosis; III. APP Structure Gives Clues to Some of Its Functions; IV. APP Is Processed via Several Distinct Enzymatic and Subcellular Pathways

V. "Alternative" Pathways of APP Metabolism Provide Clues to the Source of Aß-AmyloidVI. Aß-Amyloid Is a Normal Constituent of Body Fluids and the Conditioned Medium of Cultured Cells; VII. Evidence Suggests the Existence of an Enzyme, ß-Secretase, That Cleaves APP at the Amino Terminus of the Aß-Amyloid Domain; VIII. APP Mutations in Familial Cerebral Amyloidoses Occur within or near the Aß-Amyloid Domain, Segregate with Disease in Affected Kindreds, and Yield APP Molecules That Display Some Proamyloidogenic Properties

IX. Signal Transduction via Protein Phosphorylation Regulates the Relative Utilization of APP Processing PathwaysX. Beyond Aß-Amyloid: Other Molecular Factors in Amyloidogenesis and Factors Differentiating Aging-Related Cerebral Amyloidosis from Alzheimer Disease; References; Chapter 3. Molecular Neurobiology of the GABAA Receptor; I. Introduction; II. Pharmacology of the GABAA Receptor; III. Biochemistry; IV. Molecular Cloning of Receptor Subunits; V. Characterization of the Receptor Family; VI. The Future; Reference; Chapter 4. The Pharmacology and Function of Central GABAB Receptors

I. IntroductionII. Pharmacology of GABAB Receptors; III. Properties of GABAB Receptors; IV. Function of GABAB Receptors; V. Summary and Conclusions; References; Chapter 5.The Role of the Amygdala in Emotional Learning; I. Introduction; II. Morphology; III. Electrophysiology; IV. Anatomical Connections between the Amygdala and Brain Areas Involved in Fear and Anxiety; V. Elicitation of Fear by Electrical or Chemical Stimulation of the Amygdagdala; VI. Effects of Amygdala Lesions on Conditioned Fear; VII. Effects of Amygdala Lesions on Unconditioned Fear