The aim of the study was to examine discrimination in healthcare and psychological distress among non-immigrant and immigrant Latinos. The current study is quantitative study that utilized secondary data that was retrieved from the 2015 California Health Interview Survey (CHIS). The total sample included 5,165 Latino adults, including 2,226 (43.1%) males and 2,939 (56.9%) females. The results revealed associations between gender and poverty level on psychological distress. There were associations found on needing help from someone to understand the doctor, unfair treatment when getting medical care, and English proficiency on psychological distress. There was no significant association between citizenship status and psychological distress. Research on Latinos and discrimination continues to be limited, thus more research could help to create programming for consumers and trainings for staff to reduce health disparities for Latinos.