Background: what ails migraine research? -- Quest for a new research paradigm for migraine: why and how -- Nausea/vomiting-vasopressin nexus in migraine -- Magnesium depletion, migraine, and cellular adaptation -- Stress, brain autonomic function, BBB, and migraine -- Pupil, eyelid, and migraine -- Prolactin, melatonin, stress, and migraine -- Evoked potentials, migraine, and arousal -- The platelet-serotonin-brain neuronal connection: milestone or millstone?