Historical Evolution of Pain Concepts --History of Ion Channels in the Pain Sensory System -- The Nociceptive Membrane: Historical Overview -- TRPV1: A Polymodal Sensor in the Nociceptor Terminal -- Nociceptive Signals to TRPV1 and its Clinical Potential -- Gating, Sensitization, and Desensitization of TRPV1 -- TRP Channels as Thermosensors -- Acid Sensing Ionic Channels -- P2X Receptors in Sensory Neurons -- Voltage-Gated Sodium Channels and Neuropathic Pain -- Voltage-Gated Potassium Channels in Sensory Neurons -- Two-Pore Domain Potassium Channels in Sensory Transduction -- Finding Sensory Neuron Mechanotransduction Components -- Functional Diversity of Voltage-Dependent Ca2+ Channels in Nociception: Recent Progress in Genetic Studies -- Expression Patterns and Histological Aspects of TRP Channels in Sensory Neurons.