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Investigating the Molecules and Circuits Underlying Somatosensation
Başlık:
Investigating the Molecules and Circuits Underlying Somatosensation
Yazar:
Dong, Peter Y., author.
ISBN:
9780438036277
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (122 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Wenqin Luo; Minghong Ma Committee members: Claire H. Mitchell; Steven S. Scherer; Zhaolan Zhou.
Özet:
Somatosensation allows us to perceive sensory stimuli at the surface of the body, and includes the sensations associated with pain and itch. Under normal conditions, these sensations alert us to the presence of potential danger or irritants, but pathological manifestations of pain and itch can become chronic and highly debilitating for patients. However, many of the mechanisms underlying pain and itch remain unknown. In Chapter 1, I present an overview of the molecules mediating the initial detection of stimuli associated with pain and itch, discuss some of the current models for pain and itch circuits as information travels from the periphery to the spinal cord, and end with a review of the latest techniques involved in studying somatosensation. In Chapter 2, I investigate the role of TRPC3 in beta-alanine induced itch (Dong et al., 2017). TRPC3 is a member of the TRP family of cation-permeable ion channels and is expressed in sensory neurons, but its function within the context of somatosensation is unknown. I show that TRPC3 is dispensable for beta-alanine induced itch behavior, other acute somatosensory behaviors, and the response to beta-alanine at the cellular level. In Chapter 3, I provide insights into methods of studying how Abeta mechanoreceptor neurons modulate pain. I document the mouse genetics techniques used to obtain transgenic mouse lines that allow for the expression of light-activated opsins specifically in Abeta mechanoreceptors, and show that RetCreERT2; RosaChR2 treated mice and Split Cre; AdvillinFlp; RosaReaChR mice mediate recombination in Abeta mechanoreceptors. I then describe the caveats and challenges associated with producing these transgenic mice, such as the presence of nonspecific recombination. In sum, the findings presented here bring new insights into the mechanisms underlying itch, while offering new strategies for the study of pain mechanisms.
Notlar:
School code: 0175
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(679024.1) | 679024-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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