Systematic Pan-Cancer Analyses of the Tumor Immune Response
Başlık:
Systematic Pan-Cancer Analyses of the Tumor Immune Response
Yazar:
Varn, Frederick S., author.
ISBN:
9780438001558
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (240 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Chao Cheng Committee members: David W. Mullins; Benjamin G. Vincent; Michael L. Whitfield.
Özet:
The advent of immunotherapy represents a paradigm shift in how we study and manage cancer. By harnessing the body's intrinsic defense mechanisms, these therapies have resulted in considerable improvements in patient survival across several tumor types. Despite these promising results, a large number of patients and cancers remain unresponsive to these treatments, highlighting the individualized nature of the tumor immune response. In this thesis, we apply a systems-level approach to dissecting the tumor-immune interactions across over 20 cancer types. To accomplish this, we introduce a novel methodology for inferring immune infiltration levels of distinct cellular subsets from patient gene expression data. We then apply this methodology to multi-dimensional cancer patient datasets to better understand the factors driving the immune response in different tumors and the effect this response has on patient survival. We show that the immune infiltration landscape of different cancer types is shaped by distinct genomic factors, such as microsatellite instability and virus infection. Additionally, by performing pan-cancer survival analyses we indicate that the presence and interactions of immune cells in the tumor microenvironment exhibit associations with patient prognosis and response to immune checkpoint inhibitors independent of tumor context. Together, these analyses provide insights into how and why the immune response varies across cancer. These findings have implications for immunotherapy and provide a rationale for future studies seeking to translate patient-specific immune response activity into clinical benefit.
Notlar:
School code: 0059
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(681464.1) | 681464-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.