Synthetic approaches towards debromo-hinckdentine A
Başlık:
Synthetic approaches towards debromo-hinckdentine A
Yazar:
Corden, Steven, author.
ISBN:
9780355978322
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (181 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Özet:
Previous work done here in Manchester on the Diels-Alder reaction of the indole-2,3 double bond with 1,3-di(phenylsulphonyl)buta-1,3-diene gave access to 2- arylindole cycloadducts for the first time. However, the yields of this process and difficulties manipulating the cycloadducts towards the natural product hinckdentine A, prompted attempts at an intramolecular approach, which is described in this thesis. Attempts to produce a 1-amino-3-siloxybuta-1,3-diene in which the amine nitrogen came from 1-tosyl-2-(o-aminophenyl)indole 270 failed. The generation of a simpler N-buta-1,3-dien-1-yl derivative of 270, 308, failed to afford the cyclised product under a variety of conditions. The generation of a urea tethered diene 298 from the indole nitrogen of 2-(o- nitrophenyl)indole 268, afforded the desired 2-aryl cyclised product 300, after a 1,5-H shift of the tethered diene. The use of tri- and tetra-azines in such intramolecular reactions was investigated. The generation of 1-benzyl-2-(2-[1,2,4,5-tetrazine-3-ylamino]phenyl)indole afforded the acetylated pentacycle 325 on reaction with acetic anhydride.
Notlar:
School code: 1543
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(683868.1) | 683868-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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