The fibroblast growth factor receptor system in long term bone marrow cultures
Başlık:
The fibroblast growth factor receptor system in long term bone marrow cultures
Yazar:
Whittle, Suzanne Elaine, author.
ISBN:
9780438043596
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (193 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Özet:
The FGF receptor system comprises of a low affinity heparan sulphate receptor and a high affinity tyrosine kinase receptor. As bFGF has been shown to have a proliferative effect on the haemopoietic system, FGF receptors were investigated in murine long term bone marrow cultures. Firstly the heparan sulphate receptor from bone marrow stromal cells was characterised. It comprises of a relatively short chain, on average 26 disaccharides in length, and three sulphated domains of 3-4 disaccharides in length. Overall sulphation of the chain is high at 110 sulphates/100 disaccharides and as such provides a good structure for binding bFGF. Heparan sulphate chains are present on the cell layer and therefore will be presented in the form of a proteoglycan. Heparan sulphate proteoglycans expressed in long term bone marrow cultures were syndecan 1, syndecan 2, syndecan 4 and glypican. There are four members of the FGF tyrosine kinase receptors, three of which have alternative splicing of immunoglobulin loop III and named b/c isoforms. The specific isoforms are important when analysing the FGF receptor system, as each one is ligand specific. In murine long term bone marrow cultures FGFR 1 IIIc and FGFR 2 IIIb were expressed which are the receptors for aFGF/bFGF and aFGF/KGF respectively. The effects of these growth factors on bone marrow cultures were investigated. Both aFGF and bFGF stimulated an increase in stromal cell proliferation with bFGF having major mitogenic activity. Basic FGF also stimulated an increase in haemopoietic cell number where aFGF promoted an inhibitory response. Overall the FGF receptors within murine bone marrow are specific and therefore represent a good model to study bFGF activity.
Notlar:
School code: 1543
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(684296.1) | 684296-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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