The detection and identification of barbiturates and metabolites in biological material
Başlık:
The detection and identification of barbiturates and metabolites in biological material
Yazar:
Bogan, James, author.
ISBN:
9780438057876
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (238 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Advisors: Gilbert Forbes.
Özet:
Techniques for the extraction and identification of barbiturates in blood have been evaluated. These techniques included thin- layer chromatography, gas-liquid chromatography and mass spectrometry, A survey of the analytical results found in cases of fatal barbiturate overdosage was made and the contribution of alcohol in a number of these fatalities was assessed. The contribution of metabolically formed phenobarbitone to the anticonvulsant effect of primidone was found to be significant and the total anti-convulsant effect of primidone may be due to metabolically formed phenobarbitone. The drug prethcamide used as an analeptic in hunans has been shown previously to depress rather than stimulate respiration in the dog and thus to potentiate barbiturate anaesthesia. This was shown not to be due either to a redistribution of the barbiturate or to an alteration in the extent of protein binding of the barbiturate. The contribution of fat to the termination of the anaesthetic action of the thiobarbiturates was shown to be significant. This is contrary to recent hypotheses that fat is not of importance in short periods of anaesthesia. By liver enzyme inhibition it was demonstrated that metabolism is not of importance in lowering the blood concentrations of thiopentone in dogs. Methods were devised for the simultaneous measurement of urinary concentrations of barbiturate and barbiturate metabolite in small samples of urine, 96 hour excretion patterns were measured with five barbiturates. The thin-layer chromatographic patterns of urinary excretion products were noted and these were helpful for the identification of the parent barbiturate. Little correlation between urinary concentrations and dose administered could be established. In the Appendix, a total method for the pre-race testing of the urine of greyhounds for the presence of 'dope' is noted. This method, based on the methods from this work and a number of other standard toxicological techniques is the scheme officially adopted by the National Greyhound Racing Society and has been in satisfactory use in this country for a few years.
Notlar:
School code: 0547
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(684646.1) | 684646-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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