Nuclear Magnetic Resonance Spectroscopy in the Study of Protein-Ligand Interactions
Başlık:
Nuclear Magnetic Resonance Spectroscopy in the Study of Protein-Ligand Interactions
Yazar:
Morris, Daniel Leonard, author.
ISBN:
9780438097025
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (272 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Christopher Ziegler Committee members: Aliaksei Boika; Abraham Joy; Sailaja Paruchuri; Leah Shriver.
Özet:
Numerous nuclear magnetic resonance (NMR) experiments for observing protein-ligand interactions have been proposed over the years since NMR was first used to study biomolecules. In the work that follows, a survey of the most widely used methods is presented with applications to three protein systems. First, orthologous glutaredoxins from homo sapiens and some bacterial species were compared structurally to assay their binding interactions in a fragment-based drug discovery project. This analysis yielded ortholog specific binders to be considered as antibiotic drug leads against the glutaredoxins from Brucella melitensis and Pseudomonas aeruginosa. Next, a pedagogical research initiative was conducted along with an undergraduate biochemistry laboratory course to describe the folding and iron-sulfur cluster binding properties of the mitochondrial membrane protein mitoNEET. The students created several mitoNEET mutants and used 1D and 2D NMR experiments to characterize their effect on mitoNEET's structure and ligand binding capabilities. Finally, the lysozyme isolated from hen egg whites was observed catalyzing the polymerization of a polyacetylene. This marked the first time a hydrolase was observed catalyzing a synthetic polymer. NMR, along with X-ray crystallography, was used to describe the reaction mechanism, kinetics, and properties of the polymer product.
Notlar:
School code: 0003
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(687178.1) | 687178-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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