Long-term Survival of De Novo Stage IV Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancers Treated with HER2 Targeted Therapy
Başlık:
Long-term Survival of De Novo Stage IV Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancers Treated with HER2 Targeted Therapy
Yazar:
Wong, Yao S., author.
ISBN:
9780438132016
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (23 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Lajos Pusztai.
Özet:
Background: An increasing number of metastatic HER2 positive cancers are diagnosed as de novo stage IV disease. We hypothesize that a subset of these patients, who achieve complete clinical response or no evidence of disease (NED) status after multi-agent HER2-targeted treatments may have long progression free (PFS) and overall survival (OS).
Methods: 483 patients with de novo stage IV HER2 positive breast cancer diagnosed between 1998-2015 were identified through the medical records at Yale and MD Anderson Cancer Centers. Treatment, clinical variables and survival were extracted and compared between those who achieved NED status and those who did not.
Results: All patients received trastuzumab and 94 (20%) also received pertuzumab as first line therapy. The median OS was 5.5 years (95% Cl:4.8-6.2). Sixty-three patients (13.0%) achieved NED, their PFS and OS were 100% and 98% (95% CI:94.6%-100%) at 5 years and remined the same at 10 years. For patients with non-NED (n=420), the PFS and OS rates were 12% (95% CI:4.5%-30.4%) and 45% (95% CI:38.4%-52.0%) at 5 years, and 0%, and 4% (95% CI:1.3%-13.2%) at 10 years. There was no difference in age, grade, race, year of diagnosis, ER status, treatment distribution, or radiation between the NED and non-NED groups. NED patients more frequently had solitary metastasis (79% vs 51%, p=0.005) and surgery to resect cancer (59% vs. 22%, p≤0.001). In multivariate analysis, NED status (Hazard ratio (HR):0.014, P=0.0002) and hormone receptor positive status (HR:0.72; P=0.04) were associated with prolonged OS.
Conclusion: Achieving NED status may be an important therapeutic goal for de novo, stage IV, HER-2 positive MBC.
Notlar:
School code: 0265
Konu Başlığı:
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(688562.1) | 688562-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.