The overarching objective of this work is to develop a class of miniaturized, ultrathin, and skin mountable sensor system for mice models to record important biosignals such as temperature, pressure, EEG and EMG from the skin. The proposed studies identify a collection of miniaturized electronic components, optimized device design for the sensor system, integration strategies for construction of the system and the mounting strategy for the system on top of the mice skin. Physical properties of the system have been engineered to resemble those of the epidermis of mice, allowing the advantages in seamless, imperceptible contacts onto the skin with minimized interfacial stresses, and therefore can obviate any potential consequences that affect normal daily behavior of the mice. Embedded capabilities simultaneously allow wireless powering and data transmission in a real-time, continuous fashion. This work reported here introduces a work towards sensor systems that function without batteries and in an entirely wireless mode, with examples in thin, flexible platforms designed for miniaturized sensor systems to be deployed on top of the mouse skin. Magnetic inductive coupling and Bluetooth Low Energy (BLE) schemes have been explored in order to delivering power to the devices as well as extraction of digital data from the wearable system in ways that are compatible with standard BLE-enabled platforms, such as smartphones and computers. Examples in the monitoring of the skin temperature demonstrate the versatility of this concept. The results have potential relevance in real-time, unobtrusive monitoring for many animal studies.