The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding
Başlık:
The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding
Yazar:
Carlson, Hannah N., author.
ISBN:
9780355986853
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (65 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Wayne E. Pratt; Terry D. Blumenthal Committee members: Susan E. Fahrbach; Melissa L. Masicampo.
Özet:
Overconsumption, or eating beyond the point of homeostasis, is a key feature in the development of obesity. Although people are consuming beyond the point of homeostasis, they are not consuming constantly or indefinitely. Thus, there is likely a mechanism that acts to terminate periods of food intake at some point beyond satiation and prior to aversion, or the negative effects of extreme excess (nausea, bloating, etc.). The purpose of the present study was to assess the lateral habenula as a candidate region, due to its connectivity to midbrain reward circuitry, sensitivity to metabolic signaling, and pronounced role in drug-related motivated behaviors. Here I report that inactivation of the LHb attenuated feeding of deprived animals on a sweetened-fat diet, though impacted neither sated animals nor animals consuming a standard chow diet. However, inactivation did produce a consistent increase in locomotor activity across all conditions and in both experimental groups. Furthermore, mu-opioid stimulation increased feeding on standard chow, but decreased intake of the sweetened-fat diet. Taken together, these results suggest an important, if nuanced role, for the LHb in motivated behavior.
Notlar:
School code: 0248
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(692040.1) | 692040-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.