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Disruptions to Active Sleep in Early Life Alters Subsequent Social Development
Başlık:
Disruptions to Active Sleep in Early Life Alters Subsequent Social Development
Yazar:
Rodda, Cathleen, author. (orcid)0000-0002-8603-0467
ISBN:
9780438128316
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (165 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Jeffrey R. Alberts Committee members: John E. Bates; Laura M. Hurley; Cara L. Wellman.
Özet:
Sleep is universal, comprises a large portion of mammalian time budgets, and is vital for many aspects of life. Infant mammals spend a large portion of their overall time budget sleeping; of that sleep time, active sleep is the dominate sleep state. Infant mice spend over 80% of overall sleep time engaged in active sleep. Although much is known about the sleep of adult mammals, the behavioral outcomes following disruptions to the active sleep of infant mammals has not garnered much attention.
To disrupt active sleep, C57BL/6J mouse pups were prodded with a finger when a behavioral indicator of active sleep, myoclonic twitching, was detected. Disruptions to active sleep were accomplished in three 30-minute sessions per day over the course of 11 days, from PND 2-12. Control mice were separated from the mother and littermates and individually housed in a warm incubator for the 30-minute disruption period. Mice were then tested for social/emotional behavioral development as pre-weanlings (PND 17-19), weanlings (PND 25-30), and adults (PND 55-60).
Pre-weanling mice were tested for social behavior changes in a two-hour play test. Weanling and adult mice were tested for social encounters in the social interaction test. Additionally, the open-field test, elevated plus maze, and a sucrose preference test were conducted as tests of emotionality that might pertain to changes in social behavior. An additional control experiment was conducted to dissociate the tactile stimulation pups receive from the sleep disruption regime. In this experiment the same frequency of touching was applied with forces that did not arouse the pup from sleep. The sucrose preference test was then conducted on weanlings.
The results of my dissertation studies suggest that sleep disrupted mice develop behavioral phenotypes of timidity and relative asociality that persists into adulthood. Sleep disrupted mice exhibited deficits in play behavior, approached social stimuli less, avoided social stimuli more, showed anxiety-like behavior in the open field test, and exhibited anhedonic responses to a sucrose solution. Finally, tactile stimulation from the disruption procedure and separation from the mother and littermates were ruled out as possible confounds.
Notlar:
School code: 0093
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
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XX(694783.1) | 694783-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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