![Evaluation of Silver Nanoparticles (AgNPs) and Anti-GD2-AgNP Antibody-Drug Conjugates as Novel Neuroblastoma Therapies için kapak resmi Evaluation of Silver Nanoparticles (AgNPs) and Anti-GD2-AgNP Antibody-Drug Conjugates as Novel Neuroblastoma Therapies için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Evaluation of Silver Nanoparticles (AgNPs) and Anti-GD2-AgNP Antibody-Drug Conjugates as Novel Neuroblastoma Therapies
Başlık:
Evaluation of Silver Nanoparticles (AgNPs) and Anti-GD2-AgNP Antibody-Drug Conjugates as Novel Neuroblastoma Therapies
Yazar:
MacLeod, Haley, author.
ISBN:
9780438180390
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (100 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Craig R. Brunetti Committee members: David R. Kaplan; Leslie R. Kerr.
Özet:
Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell surface glycolipid that can provide a target for tumour-specific delivery. This study demonstrates a comprehensive evaluation of silver nanoparticles (AgNPs) and the first preliminary evaluation of anti-GD2-AgNP antibody-drug conjugates (ADCs) against NB in vitro. This present study validates the potential for AgNPs as an anti-cancer agent against NB as AgNPs demonstrated preferential toxicity towards NB cells through metabolic inhibition and indicative morphological alterations, while a less tumorigenic cell line demonstrated resistance to AgNP treatment. Therefore, this work identified an AgNP cell-type-dependent cytotoxicity effect. Low conjugation efficiency of the anti-GD2 monoclonal antibody, 14.G2a, to NHS-activated AgNPs failed to exert greater toxicity than the AgNPs alone. Collectively, this thesis provides novel information regarding the anti-cancer effects of AgNPs against NB with recommendations for anti-GD2-AgNP ADCs.
Notlar:
School code: 0513
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(695418.1) | 695418-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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