![Determining the Effects of Atypical Protein Kinase C Zeta Type (PKCzeta) on VHL Cellular Functions için kapak resmi Determining the Effects of Atypical Protein Kinase C Zeta Type (PKCzeta) on VHL Cellular Functions için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Determining the Effects of Atypical Protein Kinase C Zeta Type (PKCzeta) on VHL Cellular Functions
Başlık:
Determining the Effects of Atypical Protein Kinase C Zeta Type (PKCzeta) on VHL Cellular Functions
Yazar:
Bartley, Kelly M., author.
ISBN:
9780438106703
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (45 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Alan Schoenfeld.
Özet:
Von Hippel-Lindau Syndrome (VHL) is a genetic disorder that is characterized by the formation of highly vascularized tumors. These tumors result in a variety of different cancers such as renal cell carcinomas, hemangioblastomas, as well as phaeochromocytomas. Normally, the VHL gene prevents the formation of these tumors by binding to and ubiquitinating HIF-alpha under normal oxygen levels. Mutations in the VHL gene render the VHL protein (pVHL) unable to ubiquitinate HIF-alpha, which results in the formation of tumors. In addition to binding to HIF-alpha, VHL has been shown to bind to atypical PKC isoforms. It is unknown why this binding occurs, but VHL and atypical PKC do share similar functions. These shared functions include aiding in the formation of tight junctions and cellular polarization, regulating the expression of certain integrins, and cell motility. We investigated whether the presence of the atypical PKC, PKCzeta, was needed in order for VHL to carry out these functions. Results suggest that the absence of PKCzeta expression does not affect the proper formation of tight junctions, cell polarization, expression of alpha5 and beta1 integrins, and cell motility in the RCC10 cell line. In contrast, the absence of PKCzeta lowers the expression of HIF-alpha. PKCzeta has a function that opposes the full removal of HIF-alpha by VHL. PKCzeta does not, however, affect the other aforementioned functions.
Notlar:
School code: 0001
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696422.1) | 696422-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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