Eylem Seç
Multi-faceted Immunomodulatory and Tissue-tropic Clinical Bacterial Isolate Potentiates Prostate Cancer Immunotherapy
Başlık:
Multi-faceted Immunomodulatory and Tissue-tropic Clinical Bacterial Isolate Potentiates Prostate Cancer Immunotherapy
Yazar:
Anker, Jonathan F., author. (orcid)0000-0002-2918-0346
ISBN:
9780438125186
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (168 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Sarki A. Abdulkadir; Praveen Thumbikat Committee members: Melissa A. Brown; Derek A. Wainwright; Bin Zhang.
Özet:
Immune checkpoint inhibitors have not been effective for immunologically "cold" tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and decreased tumor burden in orthotopic MYC- and PTEN-mutant prostate cancer models. CP1 administered intra-urethrally specifically homed to and colonized tumors without causing any systemic toxicities. CP1 increased immunogenic cell death of cancer cells, T cell cytotoxicity, and tumor infiltration by activated CD8 and Th17 T cells, mature dendritic cells, M1 macrophages, and NK cells. CP1 also decreased intra-tumoral regulatory T cells and VEGF. Mechanistically, blocking CP1-recruited T cells from infiltrating the tumor inhibited its therapeutic efficacy. CP1 is a novel immunotherapeutic tool demonstrating how a tissue-specific microbe can increase tumor immunogenicity and sensitize an otherwise resistant cancer type to immunotherapy.
Notlar:
School code: 0163
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(693759.1) | 693759-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.