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Cytokines and Health Related Quality of Life: A Longitudinal Study in Breast Cancer Survivors
Başlık:
Cytokines and Health Related Quality of Life: A Longitudinal Study in Breast Cancer Survivors
Yazar:
Rao, Shruthi Konakondla Surendra, author. (orcid)0000-0003-0334-8283
ISBN:
9780438049987
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (96 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Chi-Chen Hong Committee members: Susan McCann; Amy Millen.
Özet:
Objective: Cytokine-driven inflammation is known to drive many conditions which impair a person's Health Related Quality of Life (HRQoL). We aimed to understand if self-reported HRQoL among breast cancer survivors is associated with circulating cytokines. We examined the cross-sectional associations between cytokines and HRQoL at the time of diagnosis before treatment and one year later post-treatment. We examined if cytokine levels at the time of diagnosis were associated with HRQoL at one year, and also if change in cytokines from at diagnosis to one year post-diagnosis were associated with the HRQoL at one year.
Methods: Women in the Women's Health after Breast Cancer study completed an epidemiological questionnaire which included a HRQoL assessment (Short Form-36) at breast cancer diagnosis before treatment (n=434) and one year later (n=326). Blood samples collected at diagnosis and at one year post-diagnosis were analyzed for twenty-five circulating cytokines using Luminex bead-based assays. Odds ratios (ORs) and 95% confidence intervals (CIs) for poor HRQoL (≤median) among tertiles of cytokine concentrations were estimated with multivariable logistic regression. Least squares means and 95% confidence intervals (CIs) for continuous measures of HRQoL were also estimated with linear regression by tertiles of cytokines. Trend tests were performed to check for ordered relationships across cytokine categories in both logistic and linear regression models. All analyses were adjusted for age, menopausal status, race, BMI, smoking status, education, breast cancer stage, and estrogen receptor status.
Results: Cytokines measured at diagnosis, prior to treatment, were associated with the SF-36 mental component scores (MCS), but not the physical component score (PCS) at diagnosis. Neither cytokine levels at diagnosis, nor change in cytokine levels from at diagnosis to one year post-diagnosis, were associated with HRQoL at one year post-diagnosis. There was also no associations between cytokine levels and HRQoL one year post-diagnosis. After correcting for multiple comparisons, only elevated levels of IL-6, IL-17A and TNFbeta were found to be positively associated with the MCS at the time of diagnosis.
Conclusion: Cross-sectional associations between proinflammatory cytokines and HRQoL was observed to be significant only at diagnosis, and specifically with respect to the MCS aspect of HRQoL. No significant associations were found when examining the cytokines at diagnosis and HRQoL at one year post-diagnosis, limiting our ability to understand the causality between the two. Cytokine pathways are complex and their inter-relationships with other pathways, and their role in inflammatory pathways associated with poor HRQoL in breast cancer patients are not well understood. Teasing out and identifying critical cytokines may help in designing interventions and targeted therapies to help improve HRQoL among breast cancer patients during and after treatment.
Notlar:
School code: 0656
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694171.1) | 694171-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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