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Differential Effects of Hydrocortisone on PTSD Symptom Clusters
Başlık:
Differential Effects of Hydrocortisone on PTSD Symptom Clusters
Yazar:
Garcia, Monica, author.
ISBN:
9780438071421
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (58 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Douglas Delahanty Committee members: Karin Coifman; John Gunstad; Christopher Was.
Özet:
Objective. A number of pharmacological agents have been examined for their possible efficacy at preventing/reducing the development of posttraumatic stress disorder (PTSD). These secondary interventions (administered soon after trauma) have produced mixed results, with the most promising findings being linked to early administration of hydrocortisone. However, effects have been modest, and some previous research indicates that hydrocortisone may be more efficacious in individuals without an extensive mental health history. Due to the extreme heterogeneity of PTSD, it is possible that hydrocortisone differentially impacts different PTSD symptoms. To determine if this is true, we examined whether hydrocortisone differentially impacted the different PTSD symptom clusters. As cortisol has been found to impact memory retrieval, we hypothesized that hydrocortisone would have the greatest impact on re-experiencing symptoms.
Methods. Participants (n=33) were recruited from a level 1-trauma center and were randomized into either the placebo or hydrocortisone group. Participants completed the Peritraumatic Distress Inventory and the Peritraumatic Dissociative Experiences Questionnaire at baseline, and the Davidson Trauma Scale to assess PTSD symptoms at 1- and 3-months.
Results. Using path analyses, hydrocortisone recipients reported significantly fewer re-experiencing symptoms at 1- and 3-months than placebo recipients. With respect to avoidance symptoms, medication groups did not differ at 1-month, but the hydrocortisone group reported significantly lower symptoms at 3-months. The hydrocortisone group also reported fewer hyperarousal symptoms at 1- and 3-months.
Conclusions. Despite a number of limitations, results supported our hypothesis in that hydrocortisone was efficacious at preventing the development of re-experiencing symptoms. However, hydrocortisone also demonstrated efficacy with respect to hyperarousal (at 1- and 3-months) and avoidance (at 3-months). This suggests that early hydrocortisone treatment not only impacted memory retrieval, but also physiological arousal and later avoidance/numbing symptoms. These results suggest that hydrocortisone may broadly impact the development of PTSD symptoms. Though promising, these results are considered preliminary, and should be interpreted with caution.
Notlar:
School code: 0101
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696227.1) | 696227-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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