Eylem Seç
Understanding the Molecular and Cellular Mechanisms of Salmonella Enteritidis Colonization Persistence in Layer Chicks by Examining Host, Pathogen and Microbiota Interaction
Başlık:
Understanding the Molecular and Cellular Mechanisms of Salmonella Enteritidis Colonization Persistence in Layer Chicks by Examining Host, Pathogen and Microbiota Interaction
Yazar:
Mon, Khin Khine Zar, author.
ISBN:
9780355967951
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (134 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Huaijun Zhou Committee members: Stephen McSorley; Renee Tsolis; Huaijun Zhou.
Özet:
Salmonella Enteritidis (SE) is a bacterium that primarily causes gastroenteritis infection and is commonly isolated from the hatcheries. It also poses a high zoonotic potential, causing food-borne illnesses in human after consumption of contaminated poultry products including meat and eggs. Depending on age and immunocompetence level of the avian host, SE infection is presented in two outcomes: acute/fatal or chronic salmonellosis. Persistent colonization of SE in the intestine of the chicken without apparent clinical symptoms makes it extremely challenging to detect the SE contamination in poultry farms. In addition, long-term carrier state of the infected host also serves as a reservoir for transmission of Salmonella to the naive host through the fecal-oral route, which further contributes to spreading of disease. Maintenance of overall gut homeostasis in avian hosts involves gut microbiota, its functional activities, metabolites, and optimal regulation of host immune response. Colonization resistance conferred by gut microbiota and host immune defense against the pathogen plays a prominent role in altering the course of SE invasion while contributing to the overall health status of the host. Unlike mammalian hosts that receive the direct transfer of parental microbiota, the avian host's gut environment is relatively sterile upon hatch and with increasing age colonization by members of the microbial community expands gradually. The research presented here focused on examining the dynamic interaction between host, pathogen, and gut microbiota at two different developmental stages with SE infection in layer chicks. The contributing roles of host genetic factors and early infection with SE pathogen on altering the indigenous development of microbiota composition in one-day-old layer chicks were examined. A pathogen-induced microbial shift was detected with enrichment in SE-related phylotype in the intestine that potentially further enhances disease progression in the host. The transitional development stage of gut microbiota in older layer chicks established host-microbiota homeostasis that enhances the development of the mutual metabolic relationship. Persistent high-level cecal colonization of SE in the two-week-old model, however, breaches coordinated metabolic signaling networks that exist between two interacting partners (host-commensal) to exploits available resources in the intestine to sustain its survival and replication. Furthermore, pathogen-induced redirection of host adaptive immune response towards tolerance ultimately contributed to long-term SE carrier state in layer chicks.
Notlar:
School code: 0029
Konu Başlığı:
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(678605.1) | 678605-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.