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Neural Mechanisms of Tinnitus and the Effects of Low-Level Noise Exposure on the Peripheral and Central Auditory Systems
Başlık:
Neural Mechanisms of Tinnitus and the Effects of Low-Level Noise Exposure on the Peripheral and Central Auditory Systems
Yazar:
Sheppard, Adam, author.
ISBN:
9780438047617
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (201 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Richard Salvi Committee members: Guang-Di Chen; Bohua Hu; Wei Sun.
Özet:
Subjective tinnitus, the perception of ringing or buzzing without an external sound source, and hyperacusis, an intolerance to loud sounds, can be severely debilitating disorders, and unfortunately, there remains no cure. Both tinnitus and hyperacusis are thought to emerge from aberrant neuronal hyperactivity within the central auditory system. Logically, tinnitus and hyperacusis treatment research has therefore aimed at suppressing neural activity within the central auditory system. There has been only limited success with pharmaceutical interventions; however, leveraging the auditory systems innate neuroplastic ability to alter its neural representation of sound following prolonged changes in acoustic environments has shown favorable outcomes in suppressing central hyperactivity.
The studies discussed herein investigated changes that occur in both the peripheral and central auditory systems following potential tinnitus and hyperacusis relieving agents such as potassium channel modulating drugs, and prolonged exposure to low-levels of noise. To complete these studies, detailed physiological measures representing cochlear or auditory midbrain activity were obtained following administration of potassium channel modulators or prolonged exposure to low-levels of noise with differing parameters. Our result corroborated with others that low-level noise is in fact able to alter the auditory systems central gain mechanism. Furthermore, we build on previous knowledge by characterizing the magnitude and direction of central gain changes that low-level noise is capable of inducing. Multiple factors appear to play a role in these changes, including the temporal schedule of noise exposure, and parameters of the noise such as its spectral and intensity characteristics.
Notlar:
School code: 0656
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(680927.1) | 680927-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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