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The characterisation and assessment of mature human scars
Başlık:
The characterisation and assessment of mature human scars
Yazar:
Floyd, Helen Elizabeth, author.
ISBN:
9780438082878
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (278 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Özet:
Dermal fibrosis and the remodelling of the dermis is a complex process that involves the interactions of numerous molecules. This study aims to characterise and assess the severity of mature human scars. Assessment scales were validated to assess the macroscopic and microscopic appearance of mature human normal scars, hypertrophic scars and keloids. These two scales were shown to correlate strongly. In addition, the collagen fibre orientation showed very strong correlation with the macroscopic scores. The collagen fibres were studied in more detail, using histological polarised images, fitted to a beta distribution curve. The results showed collagen fibres in scars were more aligned than normal dermal fibres, although a specific mathematical feature to provide an objective method of assessing scarring could not be found. The presence and distribution of ECM proteins, growth factors and receptors, identified using immunocytochemistry, were not found to correlate with the macroscopic scores, although some growth factors e.g. TGFbeta were upregulated in the keloids. In addition, the protease profile of normal, hypertrophic and keloid scars was assessed and found to be unaltered. One identifiable difference between the scar types was observed in the T-Cell lymphocytes population. CD4+ cells were the predominant lymphocyte sub-population present in keloids, compared to CD8+ cells in normal scars and hypertrophic scars. To conclude the dermal architecture, more specifically collagen fibres can be used to predict the severity of scarring. The spatial pattern of these ECM proteins maybe influenced by the different cell types present and, or the growth factor profile established at an earlier time point in the wound healing process.
Notlar:
School code: 1543
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(686851.1) | 686851-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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