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![Characterization of Interplay among DNA Repair, Histone H3 Lysine 9 Dimethylation and Small Interfering RNA Pathway in Caenorhabditis elegans için kapak resmi Characterization of Interplay among DNA Repair, Histone H3 Lysine 9 Dimethylation and Small Interfering RNA Pathway in Caenorhabditis elegans için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Characterization of Interplay among DNA Repair, Histone H3 Lysine 9 Dimethylation and Small Interfering RNA Pathway in Caenorhabditis elegans
Başlık:
Characterization of Interplay among DNA Repair, Histone H3 Lysine 9 Dimethylation and Small Interfering RNA Pathway in Caenorhabditis elegans
Yazar:
Yang, Bing, author.
ISBN:
9780438102439
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (140 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Eleanor Maine Committee members: John Belote; Sarah Hall; Olga Makhlynets; Melissa Pepling; David Pruyne.
Özet:
Heterochromatin assembly on repetitive sequences has been proposed to maintain genome integrity in different species. Histone H3 lysine 9 dimethylation (H3K9me2) has been shown to play an important role in mediating the formation of heterochromatin. In our lab, we use Caenorhabditis elegans as a model system to study the biological significance of the enrichment of H3K9me2 on repetitive elements and unpaired chromatin. Research of several other labs implicated that distribution of H3K9me2 on repetitive sequences limits transposon transcription and mutation occurrence near repetitive sequences. Additionally, our lab has reported that CSR-1 small RNA pathway (CSR-1, EKL-1, EGO-1 and DRH-3) regulates the deposition of H3K9me2 on unpaired chromatin during meiotic prophase.
In this study, I identified a putative DNA annealing helicase, SMRC-1, that associates with the H3K9me2 methyltransferase MET-2 and a modified form of EKL-1. The majority of this thesis focuses on understanding the interaction between MET-2 and SMRC-1. Characterization of smrc-1 mutants revealed that SMRC-1 is important for resolving replication stress. Thus the association between SMRC-1 and MET-2 might suggest H3K9me2 functions as an epigenetic regulator of double strand break formations genome wide. Additionally, I found that a modified form of EKL-1 might interact with SMRC-1. Based on these findings, I propose a model whereby SMRC-1 bridges the CSR-1 small RNA pathway with H3K9me2.
Notlar:
School code: 0659
Konu Başlığı:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(689958.1) | 689958-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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