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Alternative Biological Roles of Methionine Sulfoxide Reductases in Drosophila melanogaster
Başlık:
Alternative Biological Roles of Methionine Sulfoxide Reductases in Drosophila melanogaster
Yazar:
Wilson, Kelsey, author. (orcid)0000-0001-5419-5454
ISBN:
9780438011533
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (79 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: David Binninger Committee members: Ken Dawson-Scully; Alex Keene; Xing-Hai Zhang.
Özet:
The oxidation of methionine (Met) into methionine sulfoxide (met-(o)) leads to deleterious modifications to a variety of cellular constituents. These deleterious alterations can be reversed by enzymes known as methionine sulfoxide reductases (Msr). The Msr (MsrA and MsrB) family of enzymes have been studied extensively for their biological roles in reducing oxidized Met residues back into functional Met. A wide range of studies have focused on Msr both in vivo and in vitro using a variety of model organisms. More specifically, studies have noted numerous processes affected by the overexpression, under expression, and silencing of MsrA and MsrB. Collectively, the results of these studies have shown that Msr is involved in lifespan and the management of oxidative stress. More recent evidence is emerging that supports existing biological functions of Msr and theorizes the involvement of Msr in numerous biological pathways.
Notlar:
School code: 0119
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(690350.1) | 690350-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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