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AGO2 overexpression exhibits oncogenic functions in Kras G12D-associated mouse tumor models
Başlık:
AGO2 overexpression exhibits oncogenic functions in Kras G12D-associated mouse tumor models
Yazar:
Thai, Kevin K., author.
Yazar Ek Girişi:
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Tyler E. Jacks.
Özet:
Cancer is a disease of normal healthy cells that have accumulated genetic aberrations that contribute to uncontrolled cell divisions. Generally, cancer cells have acquired gain of function mutations in oncogenes that positively promote cell proliferation and growth. Simultaneously, mutations in tumor suppressor genes are frequently detected, allowing cells to evade cell cycle checkpoints, resulting in the inhibition of cell death signals. Therefore, identifying genetic abnormalities that promote tumor initiation and progression is imperative in the development of targeted therapeutics. This thesis focuses on the role of Argonaute-2 in promoting cellular transformation in mouse model systems, highlighting novel oncogenic functions associated with AGO2 overexpression. In short, we have determined that AGO2 overexpression promotes metastasis in an autochthonous mouse model of non-small cell lung cancer while elevated AGO2 levels in B cells contribute to the initiation and maintenance of activated B cell-like diffuse large B cell lymphoma (ABC-like DLBCL), both in the context of KRAS activation and Tp53 deletion. (Copies available exclusively from MIT Libraries, libraries.mit.edu/docs - docs mit.edu).
Notlar:
School code: 0753
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696967.1) | 696967-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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