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Changes in NLRP3 Inflammasome After Mindfulness Training: An Ancillary Analysis of Data from the Shine Randomized Clinical Trial
Başlık:
Changes in NLRP3 Inflammasome After Mindfulness Training: An Ancillary Analysis of Data from the Shine Randomized Clinical Trial
Yazar:
Kutler, Lynn Frances, author.
ISBN:
9780438131798
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (156 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Donelle M. Barnes.
Özet:
This ancillary analysis of data from the SHINE randomized clinical trial investigated the relationships between perceived stress, trait mindfulness, and NLRP3 inflammasome activation.
Non-communicable diseases such as cardiovascular disease, type 2 diabetes, and some cancers are an emerging public health challenge. These diseases manifest in different ways physiologically, however, they have similar molecular response profiles from which they emerge. This includes the activation of the NLRP3 inflammasome, implicated in the inflammatory nature of psychological stress as a precursor non-communicable disease. This study investigated the change in the genomic expression of the NLRP3 inflammasome in subjects who received mindfulness training compared to those who have not and is significant as the first investigation to approach this question in this way.
Participants (n = 194) in the SHINE RCT were randomly assigned to a control or experimental group; the latter received mindfulness training around eating and stress management. Data were collected from multiple physiologic and quantitative measures using instruments with previously established reliability and validity. Variables of interest in this study were stress, measured using the Perceived Stress Scale; trait mindfulness measured using the non-reactivity subscale of the Five Facet Mindfulness Questionnaire; and NLRP3 inflammasome measured in peripheral mononuclear blood cells samples collected at baseline and 6 months. Complete data on these three variables existed for 136 participants.
Data were analyzed with Pearson product moment correlations ( r), t-tests and gain score analysis. There were no significant relationships among any of the study variables; computed effect size was 0. Analysis of the results revealed smaller than anticipated sample and effect sizes which likely influenced the findings rather than a lack of theoretical consistency.
This is an emerging area of inquiry in nursing research; further studies are warranted to understand the relationships between mindfulness and genomic variables at the molecular level.
Notlar:
School code: 2502
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696878.1) | 696878-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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