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Therapeutic Drug Monitoring of Tacrolimus in Jordanian Kidney Transplant Patients
Başlık:
Therapeutic Drug Monitoring of Tacrolimus in Jordanian Kidney Transplant Patients
Yazar:
Banna, Fathia Jehad, author.
ISBN:
9780438022355
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (95 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Nasir Idkaidek; Salim Hamadi Committee members: Ibrahim Al-Adham; Izzat Al-Awwa; Salim Hamadi; Nasir Idkaidek; Eyad Mallah.
Özet:
Tacrolimus is a macrolide antibiotic with immunosuppressive properties, it is indicated as primary immunosuppressive therapy following liver, heart and kidney transplantation, because of its better survival results and less acute cellular rejection than cyclosporine. The main objectives of this study are to investigate the robustness of using a non- invasive saliva sampling method instead of a blood sampling method as a surrogate for therapeutic drug monitoring (TDM) of tacrolimus among Jordanian patients, develop validated, sensitive and specific method (LC-MS/MS) for determination of tacrolimus in blood and saliva, determine the correlation between blood tacrolimus concentration versus saliva tacrolimus concentration and determine the variability in pharmacokinetic parameters of tacrolimus among patients to individualize dosage regimen. The benefits of using saliva instead of blood for therapeutic drug monitoring are that saliva is simple, cheap, non- invasive technique and doesn't require expertise of drawing blood. A liquid chromatography- mass spectrometry (LC-MS/MS) assay method was developed and validated for the determination of tacrolimus in blood and saliva. Forty two patients participated in this study. Two samples were collected from each patient two hours before morning dose, one sample is blood and another is resting saliva sample. Microsoft Excel program was used for descriptive statistics and t- testing, ANOVA, P- value of 0.05 was adopted for significant difference. Optimized effective intestinal permeability of tacrolimus was estimated by PK-Sim program version 7, which classified tacrolimus as class III based on Salivary Excretion Classification System (SECS). A good correlation of 0.51 between blood and saliva concentrations was observed, which indicate that saliva sampling is a good alternative matrix for tacrolimus TDM. Mean blood tacrolimus concentrations and mean saliva tacrolimus concentrations are 4.15 ng/ml and 0.93 ng/ml, respectively, with a mean ratio equal 0.286. Predicted normal tacrolimus therapeutic range after the first six months of transplantation for both blood and saliva are (2.73 - 3.82) ng/ml and (0.93 - 1.3) ng/ml, respectively.
Notlar:
School code: 1773
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694601.1) | 694601-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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