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Head and Thorax Elevation During Active Compression Decompression Cardiopulmonary Resuscitation with an Impedance Threshold Device Improves Cerebral Perfusion in a Swine Model of Prolonged Cardiac Arrest
Başlık:
Head and Thorax Elevation During Active Compression Decompression Cardiopulmonary Resuscitation with an Impedance Threshold Device Improves Cerebral Perfusion in a Swine Model of Prolonged Cardiac Arrest
Yazar:
Moore, Johanna Catherine, author.
ISBN:
9780438030886
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (27 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Michelle H. Biros Committee members: Keith G. Lurie; James R. Miner.
Özet:
Aim: To compare brain blood flow between the head up (HUP) and supine (SUP) body positions during prolonged cardiopulmonary resuscitation (CPR), using active compression-decompression (ACD) CPR and an impedance threshold device (ITD) in a swine model of cardiac arrest.
Methods: After 8 minutes of untreated ventricular fibrillation (VF), followed by 2 minutes of ACD-CPR+ITD in the SUP position, pigs were randomized to 18 minutes of ACD-CPR+ITD in either 30o HUP or SUP position. Microspheres were injected before VF, and then 5 and 15 minutes after study start.
Results: Brain Blood flow (ml/min/g, mean +/- SD) after 15 minutes of CPR was 0.42+/-0.05 for HUP (n=8) and 0.21+/-0.04 for SUP (n=10), (p<0.01). The HUP group also had lower intracranial pressures and higher cerebral perfusion pressures.
Conclusions: Brain blood flow in the HUP position was higher in than the SUP position. This provides pre-clinical support to proceed with a clinical evaluation of head up CPR in humans.
Notlar:
School code: 0130
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