Front Cover; Annual Reports in Medicinal Chemistry, Volume 27; Copyright Page; Contents; Contributors; Preface; SECTION I: CNS AGENTS; Chapter 1. The Decade of the Brain; Chapter 2. Pharmacological Intervention in Sleep and Circadian Processes; Chapter 3. Advances in Central Serotoninergics; Chapter 4. Traumatic and Ischemia/Reperfusion Injury to the CNS; Chapter 5. Trophic Factors and their Receptors in the CNS; Chapter 6. Antipsychotics; SECTION II: CARDIOVASCULAR AND PULMONARY AGENTS; Chapter 7. Angiotensin/Renin Modulators; Chapter 8. EDRF, an Emerging Target for Drug Design

Chapter 9. Endogenous Vasoactive PeptidesChapter 10. Recent Advances in Antiarrhythmic Therapy: Potassium Channel Antagonists; Chapter 11. Future Antithrombotic Therapy; Chapter 12. Pulmonary and Anti-Allergy Agents; SECTION III: CHEMOTHERAPEUTIC AGENTS; Chapter 13. Antibacterial Agents, Targets and Approaches; Chapter 14. Genetic Engineering of Antibiotic Producing Organisms; Chapter 15. Inhibitors of Angiogenesis; Chapter 16. Recent Advances in Antifungal Agents; Chapter 17. Progress in Antimicrobial Peptides; Chapter 18. Protein Tyrosine Kinases and Cancer

SECTION IV: IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC DISEASESChapter 19. Monoclonal Antibodies in Therapy; Chapter 20. Techniques for Determining Epitopes for Antibodies and T-cell Receptors; Chapter 21. Potential Therapeutic Modifers of the Complement Cascade; Chapter 22. Cytokine Modulation as a Medicinal Chemistry Target; Chapter 23. Recent Advances in the Discovery and Development of Potential Antidiabetic Agents; SECTION V: TOPICS IN BIOLOGY; Chapter 24. The Role of Homeobox Genes in Vertebrate Embryonic Development; Chapter 25. Emerging Therapies for Cystic Fibrosis

Chapter 26. The Guanylyl Cyclase Family of Receptor/EnzymesChapter 27. HIV Vaccine Development: From Empiricism to Medicinal Chemistry; Chapter 28. Inositol Triphosphate Receptors; SECTION VI: TOPICS IN DRUG DESIGN AND DISCOVERY; Chapter 29. Macromolecular X-Ray Crystallography and NMR as Tools for Structure-Based Drug Design; Chapter 30. Three-dimensional Models of G-Protein Coupled Receptors; Chapter 31. Carbohydrates as Drug Discovery Leads; Chapter 32. Sequence-Specific DNA Binding and the Regulation of Eukaryotic Gene Transcription; SECTION VII: TRENDS AND PERSPECTIVES

Chapter 33. To Market, To Market -- 1991COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX, VOLUME 27; CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 1-27; CUMULATIVE NCE INTRODUCTION INDEX, 1983-1991; CUMULATIVE NCE INTRODUCTION INDEX, 1983-1991, BY INDICATION