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The Effects of MsrA and MsrB in Anoxia Tolerance in Aging Drosophila melanogaster
Başlık:
The Effects of MsrA and MsrB in Anoxia Tolerance in Aging Drosophila melanogaster
Yazar:
Suthakaran, Nirthieca, author.
ISBN:
9780438013681
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (79 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: David Binninger Committee members: Sarah Milton; Howard Prentice.
Özet:
Drosophila melanogaster tolerates several hours of anoxia (the absence of oxygen) by entering a protective coma. A burst of reactive oxygen species (ROS) is produced when oxygen is reintroduced to the cells. ROS causes oxidative damage to critical cellular molecules, which contribute to aging and development of certain age-related conditions. The amino acid, methionine, is susceptible to oxidation, although this damage can be reversed by methionine sulfoxide reductases (Msr). This project investigates the effect of Msr-deficiency on anoxia tolerance in Drosophila throughout the lifespan of the animal. The data show that the time for recovery from the protective comma as well as the survival of the animals lacking any Msr activity depends on how quickly the coma is induced by the anoxic conditions. Insight into the roles(s) of Msr genes under anoxic stress can lead us to a path of designing therapeutic drugs around these genes in relation to stroke.
Notlar:
School code: 0119
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(693326.1) | 693326-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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