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Copper Catalyzed SP3 C-H Functionalization for C-O, C-N, and C-C Bond Formation
Başlık:
Copper Catalyzed SP3 C-H Functionalization for C-O, C-N, and C-C Bond Formation
Yazar:
Salvador, Tolani Kuam, author.
ISBN:
9780438121171
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (186 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Timothy H. Warren; Christopher Uyeda Committee members: Mingji Dai; Suzanne C. DOUCETTE BART C. Doucette Bart.
Özet:
C-H functionalization allows us to convert C-H bonds into a variety of functional groups. Using copper as a catalyst with tBuOO tBu as an oxidant, we have been successful in converting sp 3 C-H bonds into new C-O, C-N, and C-C bonds. Aliphatic alcohols afford dialkyl ether products using a variety of R-H substrates enabling the construction of diverse set of compounds. Overcoming the limitation that phenols don't afford desired ether products efficiently, we are able to use acyl protected phenols to generate aryl alkyl ethers. Expanding on this approach of protecting group exchange, TMSNCO affords boc-protected amines from different R-H substrates in high yields. Triaryl and trialkyl boranes appears to be efficient transmetallating sources upon reacting with different R-H substrates to generate new sp 3 -- sp3 bond or new a sp2- p 3 bond. Rarely observed in literature, our chemistry allows us to access sterically hindered R-H substrates enabling us to construct hindered species. We have also been successful in isolating key intermediates allowing us further mechanistic insight into our proposed mechanisms.
Notlar:
School code: 0183
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(687810.1) | 687810-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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