![](/client/images/blank.gif)
Eylem Seç
![High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution için kapak resmi High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution
Başlık:
High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution
Yazar:
Ma, Junyan, author.
ISBN:
9780438053533
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (110 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Hugo Sanabria Committee members: Tennyson Andrew; Feng Ding; Casabianca Leah.
Özet:
Forster Resonance Energy Transfer (FRET) is a promising methodology which is used by researchers in determining structural information of biomolecules. Other methodologies such as X-ray diffraction, nuclear magnetic resonance (NMR) and electron microscopy (EM), and X-ray scattering (SAXS) and circular dichroism (CD) can only give snapshots of the functional conformers. In the applications of most cases, FRET can only be used to give a qualitative result such as "yes" or "no" pattern. In our lab, we are able to expand this ability by applying FRET to quantitatively determine the structure and dynamic information in the biological system with high accuracy.
We first apply this methodology in measuring our standard double strand DNA in order to identify its ability to obtain the interdye distance with high accuracy. Then, we are able to identify the fast dynamic which happens in mRNA followed by a kinetic pathway of its folding pattern. Finally, we used FRET as well as discrete molecular dynamics (DMD) simulation in determining dynamic behavior of PDZ domains.
Notlar:
School code: 0050
Konu Başlığı:
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(679241.1) | 679241-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.