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![Investigation into the Mechanism of Catalysis for the Kinetic Resolution of alpha,alpha-Disubstituted gamma-Hydroxy Esters için kapak resmi Investigation into the Mechanism of Catalysis for the Kinetic Resolution of alpha,alpha-Disubstituted gamma-Hydroxy Esters için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Investigation into the Mechanism of Catalysis for the Kinetic Resolution of alpha,alpha-Disubstituted gamma-Hydroxy Esters
Başlık:
Investigation into the Mechanism of Catalysis for the Kinetic Resolution of alpha,alpha-Disubstituted gamma-Hydroxy Esters
Yazar:
Wilson, Gregory Tyler, author.
ISBN:
9780438087705
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (120 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Kimberly S. Petersen Committee members: Mitchell Croatt; Jason Reddick; Jerome Walsh.
Özet:
The synthesis of enantioenriched, biologically active compounds is a vital area of interest for synthetic chemists. The lactone motif is found in several biologically important molecules, and the development of kinetic resolutions capable of producing enantioenriched lactones is important for the total synthesis of these types of compounds. The chiral Bronsted-acid catalyst, R-TRIP, has proven to be effective in producing enantioenriched alpha,alpha-disubstituted lactones with up to 94% ee. A study of the effects of varying electronic substituents on the kinetic resolution of alpha,alpha-disubstituted-gamma-hydroxy esters to produce enantioenriched gamma-lactones is the focus of this study. The introduction of varying electron-withdrawing and electron-donating substituents in the para position of an alpha-Ph group is hypothesized to cause a change in the selectivity and rate of reaction through resonance, induction, hydrogen bonding and pi-stacking. This project seeks to broaden the scope and understanding of the catalyst-substrate interaction to improve upon this synthetic methodology.
Notlar:
School code: 0154
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(689735.1) | 689735-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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