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Analogs of Natural Product FR900098 as Small Molecule Inhibitors for the Methylerythritol Phosphate (MEP) Pathway in Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf)
Başlık:
Analogs of Natural Product FR900098 as Small Molecule Inhibitors for the Methylerythritol Phosphate (MEP) Pathway in Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf)
Yazar:
Wang, Ruiqin, author.
ISBN:
9780355987720
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (153 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Cynthia S. Dowd Committee members: Cynthia S. Dowd; Michael M. King.
Özet:
Mycobacterium tuberculosis (Mtb) and Plasmodium falciparum (Pf) are very prevalent and deadly species affecting millions of people's lives while causing lots of infection-related deaths every year. Effective drugs discovered in the past are now facing great challenges such as multi-drug resistance. Due to the urgent need to discover efficacious molecules that can kill Mtb and Pf through novel modes of actions, we have designed, synthesized, and tested a series of analogs of a natural product, FR900098. These compounds were synthesized aiming to block 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), the second step of the methyl erythritol 4-phosphate (MEP) pathway. Out of the eighteen molecules in this series, SRW-61 has shown the best Pf whole cell inhibition.
Notlar:
School code: 0075
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(693970.1) | 693970-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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