![](/client/images/blank.gif)
Eylem Seç
![Amide Bond Modulation: Partial Amide Bond Rotation in Cyclic Amines of DEET Analogs Follow an Enthalpy-Entropy Compensation (EEC) için kapak resmi Amide Bond Modulation: Partial Amide Bond Rotation in Cyclic Amines of DEET Analogs Follow an Enthalpy-Entropy Compensation (EEC) için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Amide Bond Modulation: Partial Amide Bond Rotation in Cyclic Amines of DEET Analogs Follow an Enthalpy-Entropy Compensation (EEC)
Başlık:
Amide Bond Modulation: Partial Amide Bond Rotation in Cyclic Amines of DEET Analogs Follow an Enthalpy-Entropy Compensation (EEC)
Yazar:
Guerra, Jacob, author.
ISBN:
9780438114425
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (245 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Santanu Maitra Committee members: Laurent Dejean; Viswanathan Krishnan.
Özet:
Recently, studies using nuclear magnetic resonance (NMR) spectroscopy on analogs of the pest repellent m-DEET have shown that a third higher energy trapped conformation exists with some ortho substitutions and is evident as the third set of methylene peaks in the 3.4-3.6ppm chemical shift range. Further, studies have also shown that DEET's amide bond has the potential to be altered by electronic and steric interactions. Based on these findings, we explore further thermodynamic insight that can be gained by altering the size and magnitude of electron withdrawing/donating aromatic substituents in combination with cyclic amines. Our long-term goal is to understand how thermodynamic principles affect amide bond rotation and use this information toward improving DEET's ligand efficiency as an odorant. Eyring analysis of variable temperature NMR spectra suggests that enthalpy and entropy of the transition state for all 48 analogs synthesized follows an enthalpy-entropy compensation (EEC) mechanism and limited to a relatively small window of Gibbs energy of the transition state. Using an EEC plot gives a better idea as to how changes to DEET's structure alter the Gibbs energy of the transition state.
Notlar:
School code: 6050
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(695465.1) | 695465-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.